Table 1.
Genes induced by OxyR during hydrogen peroxide stress in E. coli.
| Gene | Function | Role during H2O2 stress |
|---|---|---|
| ahpCF | NADH peroxidase | Scavenge H2O2 |
| katG | Catalase | |
| ccp | Cytochrome c peroxidase | Uses H2O2 as a terminal electron acceptor |
| dps | Mini-ferritin | Reduce the intracellular iron pool |
| fur | Repressor of iron import | |
| yaaA | Unknown | |
| clpSA | Chaperone | Activate Fe/S enzymes |
| sufA-E | Iron sulfur-assembly | |
| hemF | Coproporphyrinogen III oxidase | Heme synthesis |
| hemH | Ferrochelatase | |
| mntH | Manganese importer | Activate mononuclear Fe enzymes |
| gor | Glutathione reductase | Maintain the thiol status |
| trxC | Thioredoxin | |
| grxA | Glutaredoxin 1 | |
| oxyS | Non-coding RNA | Role unknown |
| isrC | Non-coding RNA | |
| flu | Antigen 43 | |
| fhuF | Ferric iron reductase |