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. 2021 May 12;7:39. doi: 10.1038/s41531-021-00182-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Stacked bar charts show the percentage of neurons carrying different numbers of affected RC complexes that show a decreased level of expression in each group. Within each category, components of the ‘decreased’ neuronal population were colour-coded to show the proportion of each individual complex involved. For those complexes with two subunits tested, NDUFA13, MTCO1 and ATP5B were selected to represent the expression of complex I, IV and V respectively. Number of neurons analysed: PD, n = 63; POLG, n = 133; control, n = 42. b Regression analysis of the number of OxPhos complexes showing a decreased expression and age in the control cases (r² = 0.07, p < 0.001). Each data point represents an individual neuron with separate controls highlighted by colour, for each neuron the number of proteins for which that neuron was classed as being deficient was determined. Lines and shadow represent the linear regression line and the 95% prediction interval. c Analysis of the percentage of neurons carrying different numbers of affected RC complexes that show a decreased level of expression in each group was also performed in the neuronal population with complex I decreased expression.