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. 2021 May 12;7:39. doi: 10.1038/s41531-021-00182-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a–e Heatmaps to illustrate the percentage of neurons which show a decreased level of protein expression within each individual complex among the five categories of deficient neuronal populations (complex I–V deficient neurons respectively). f–j These are shown alongside the same percentage calculations within the corresponding normal neuronal populations. Cases with no deficient neurons were excluded from this analysis. k–o Using Bayesian estimation, the difference of means (µ1–µ2; µ1-decreased, µ2-normal) of mitochondrial mass (VDAC1) between the decreased and normal neurons of each individual case was analysed and compared between groups. Only cases with three or more neurons which fell into each category were included. Group comparison of the µ1–µ2 value of each individual was also performed (Mann–Whitney test, *p < 0.05). Dot sizes represent the values of the effect size.