Table 1.
Absorbed dose estimates for 89Zr-labeled CAR T cells and 68Ga-labeled CAR T cells in selected organs
| Target organ | Effective dose (mSv/MBq) | |
|---|---|---|
| 89Zr | 68Ga | |
| Adrenals | 3.13×10−2 | 2.13×10−4 |
| Brain | 3.01×10−4 | 4.63×10−6 |
| Esophagus | 4.23×10−2 | 6.58×10−4 |
| Eyes | 0.00×1000 | 0.00×1000 |
| Gallbladder wall | 1.43×10−2 | 1.45×10−4 |
| Left colon | 4.54×10−2 | 3.20×10−4 |
| Small intestine | 3.73×10−3 | 2.81×10−5 |
| Stomach wall | 2.25×10−1 | 2.23×10−3 |
| Right colon | 2.55×10−2 | 2.17×10−4 |
| Rectum | 2.33×10−3 | 1.55×10−5 |
| Heart wall | 8.80×10−3 | 1.75×10−4 |
| Kidneys | 1.65×10−2 | 1.18×10−4 |
| Liver | 1.41×10−1 | 3.60×10−3 |
| Lungs | 2.69×10−1 | 3.50×10−2 |
| Pancreas | 1.18×10−2 | 9.82×10−5 |
| Prostate | 5.89×10−4 | 3.75×10−6 |
| Salivary glands | 6.67×10−4 | 1.15×10−5 |
| Red marrow | 6.00×10−2 | 7.68×10−4 |
| Osteogenic cells | 2.78×10−3 | 3.37×10−5 |
| Spleen | 3.65×10−1 | 8.79×10−3 |
| Testes | 6.91×10−4 | 3.61×10−6 |
| Thymus | 5.14×10−3 | 1.10×10−4 |
| Thyroid | 1.46×10−2 | 3.74×10−4 |
| Urinary bladder wall | 2.45×10−3 | 1.61×10−5 |
| Total Body | 1.29×1000 | 5.30×10−2 |