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. 2020 Aug 7;42(5):735–743. doi: 10.1038/s41401-020-0493-4

Fig. 5. The effect of berberine is independent of endothelial-dependent vasodilation.

Fig. 5

a Western blot analysis of p-eNOS (Ser1177) and total eNOS in HUVECs. b Animal study protocol. Rats received an intralipid + heparin (6.6%, 30 U/mL) infusion with or without BBR (10 mg/kg) i.g. delivery 1 h before the insulin clamp in the presence or absence of NO inhibitor NG-nitro-L-arginine (L-NAME, 50 μg · kg−1 · min−1) infusion. c Time courses of the glucose infusion rate (GIR) during euglycemic-hyperinsulinemic clamps. The data are shown as the mean ± SD. ***P < 0.001 vs. intralipid group, n = 3–4. d Steady-state GIR. The data are shown as the mean ± SD. ***P < 0.001 vs. intralipid group; ns not significant; n = 3–4.