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. 2020 Sep 13;46(6):1093–1102. doi: 10.1038/s41386-020-00847-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The scatterplots represent the IV effects on the exposure and outcome variables (black point), with the confidence intervals for both estimates denoted by the horizontal and vertical lines, respectively. Each coloured slope is indicative of the causal effect of a unit increase in the exposure on the outcome, estimated by the method in the legend utilised to shade the trendline – that is, inverse-variance weighted effect with multiplicative random effects (light blue), weighted median (light green), weighted mode (dark green), and MR-Egger (dark blue). The four panels correspond to a different exposure-outcome pair: (a) fasting insulin → anorexia nervosa, (b) fasting insulin → major depressive disorder, (c) anorexia nervosa → HbA1c, and (d) schizophrenia → fasting insulin.