Table 2.
Results of histopathological and immunohistochemical analyses of brain and heart samples, with partial and global arbitrary scores.
Animal | Brain | Total Score | Heart | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histology | IHC | Histology | IHC | |||||||||||
MI | Tu | Ty | De | S100B | GFAP | Score | Score | MI | Tu | MA | TnC | D | ||
ACA1 | 0 | 1 | 0 | 0 | 1 | 1 | 3 | 7 | 4 | 0 | 1 | 1 | 1 | 1 |
ACA2 | 0 | 1 | 0 | 0 | 1 | 1 | 3 | 7 | 4 | 0 | 1 | 1 | 1 | 1 |
ACA3 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 5 | 3 | 0 | 0 | 1 | 1 | 1 |
ACA4 | 1 | 3 | 1 | 1 | 3 | 3 | 12 | 25 | 13 | 1 | 3 | 3 | 3 | 3 |
ACA5 | 1 | 2 | 1 | 1 | 2 | 2 | 9 | 17 | 8 | 0 | 2 | 2 | 2 | 2 |
ACA6 | 1 | 2 | 1 | 1 | 3 | 3 | 11 | 23 | 12 | 1 | 2 | 3 | 3 | 3 |
ACA7 | 0 | 1 | 0 | 0 | 1 | 2 | 4 | 10 | 6 | 0 | 1 | 2 | 1 | 2 |
ACA8 | 0 | 1 | 0 | 0 | 1 | 1 | 3 | 8 | 5 | 0 | 1 | 2 | 1 | 1 |
ACA9 | 1 | 3 | 1 | 1 | 3 | 3 | 12 | 25 | 13 | 1 | 3 | 3 | 3 | 3 |
ACA10 | 1 | 2 | 1 | 1 | 2 | 3 | 10 | 19 | 9 | 0 | 2 | 2 | 2 | 3 |
VFCA1 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 5 | 3 | 0 | 0 | 1 | 1 | 1 |
VFCA2 | 0 | 1 | 0 | 1 | 2 | 1 | 5 | 13 | 8 | 0 | 2 | 2 | 2 | 2 |
VFCA3 | 0 | 1 | 0 | 0 | 1 | 1 | 3 | 7 | 4 | 0 | 1 | 1 | 1 | 1 |
VFCA4 | 0 | 2 | 1 | 1 | 3 | 2 | 9 | 18 | 9 | 0 | 2 | 3 | 2 | 2 |
VFCA5 | 0 | 0 | 0 | 0 | 1 | 1 | 2 | 6 | 4 | 0 | 1 | 1 | 1 | 1 |
VFCA6 | 0 | 1 | 0 | 0 | 2 | 1 | 4 | 8 | 4 | 0 | 1 | 1 | 1 | 1 |
VFCA7 | 0 | 0 | 0 | 0 | 2 | 1 | 3 | 7 | 4 | 0 | 1 | 1 | 1 | 1 |
VFCA8 | 0 | 0 | 0 | 0 | 2 | 1 | 3 | 6 | 3 | 0 | 1 | 1 | 1 | 0 |
VFCA9 | 0 | 1 | 0 | 0 | 3 | 2 | 6 | 12 | 6 | 0 | 1 | 2 | 1 | 2 |
VFCA10 | 0 | 2 | 1 | 1 | 3 | 2 | 9 | 18 | 9 | 0 | 2 | 3 | 2 | 2 |
IHC = Immunohistochemistry; MI = Micro-Infarction; Tu = TUNEL; Ty = Tygrolisis; De = Demyelination; MA = Morphological alterations; GFAP = Glial Fibrillary Acid Pro; TnC = C-Troponin; D = Desmin.
Assigned scores: MI, Ty, De: 0 = absent, 1 = present; MA, 0 = absent, 1 = mild, 2 = moderate, 3 = severe; Tu: 0 = absent, 1 = up to 2%, 2 = up to 5%, 3 = more than 5%; S100B, GFAP, D, TnC: 0 = absent, 1 = mild, 2 = moderate, 3 = severe.