Table 2.

Parameter estimates for all main effects and significant interactions.

	Estimate	SE	95% confidence interval		z	p
			Lower	Upper
(A)
Gender	−0.74	1.49	0.03	8.85	−0.50	0.619
Diagnosis	−3.66	1.49	0.001	0.48	−2.45	0.015
Age	−0.66	0.06	0.46	0.58	−11.42	<0.001
(B)
Age	−0.58	0.10	−0.78	−0.37	−5.51	<0.001
Motor/non-planning impulsivity	0.74	0.99	−1.21	2.68	0.74	0.461
Motor impulsivity	−0.70	1.02	−2.70	1.30	−0.69	0.496
Attentional impulsivity	1.75	1.11	−0.44	3.93	1.57	0.122
Deficits in problem solving	−0.21	1.03	−2.23	1.80	−0.21	0.835
Financial impulsivity	3.08	1.00	1.11	5.05	3.07	0.003
HDRS	0.79	0.33	0.14	1.43	2.39	0.019
Gender	−3.72	2.21	−8.04	0.60	−1.69	0.096
HDRS score*Gender	−2.27	0.69	−3.62	−0.92	−3.29	0.002
(C)
Gender	9.39	5.96	−2.29	21.06	1.58	0.119
Age	0.36	0.30	−0.24	0.95	1.17	0.244
PAD	0.11	0.28	−0.44	0.66	0.40	0.693
Group (1 Hz > 20 Hz)	0.08	7.75	−15.11	15.27	0.01	0.992
Group (Placebo > Active)	1.20	6.64	−11.81	14.22	0.18	0.857
PAD*Group (1 Hz >20 Hz)	−0.13	0.56	−1.23	0.98	−0.22	0.824
PAD*Group (Placebo > Active)	1.43	0.49	0.48	2.39	2.94	0.004

(A) GLM assessing brain-PAD in MDD and HC. (B) GLM assessing pretreatment clinical measures (BIS-11 factors and HDRS) and brain-PAD in the MDD group. (C) GLM assessing the relationship between brain-PAD and TMS response. Bold and underlined uncorrected p values are significant after multiple comparisons correction. All parameter estimates are summarized in Supplementary Table S3.

HDRS Hamilton Rating Scale for Depression, PAD brain-predicted age difference score.