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. 2021 May 12;11:10079. doi: 10.1038/s41598-021-89551-3

Figure 1.

Figure 1

Systemic pro-inflammatory, anti-viral, Th1, Th2, Th17, pleiotropic and anti-inflammatory cytokines across pregnancy. (A) Pro-inflammatory (IL-1β, TNF-α, IP-10, IL-8), (B) anti-viral (IFNα2, IFNβ, IFNλ1, IFNλ2/3), (C) Th1 (IFNγ, IL-2, IL-12p70), (D) Th2 (IL-4, IL-5, IL-13), (E) Th17 (IL-17A, IL-17F, IL-21, IL-22) and (F) pleiotropic and anti-inflammatory (IL-6, IL-9, GM-CSF and IL-10 respectively) cytokines were measured in maternal plasma collected during the first (T1), second (T2) and third (T3) trimester. Data are presented as the percentage of samples in which cytokines were detected by multiplex cytokine assay. *P < 0.05.