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. 2021 Feb 8;46(5):949–958. doi: 10.1038/s41386-021-00970-2

Fig. 1. Chronic adolescent stress (CAS) led to anxiety-like behavior and male-specific social avoidance.

Fig. 1

A Female and male rats of NS or CAS background were behaviorally tested once in adolescence on postnatal day (PND)50, and again in adulthood on PND91. B Adolescent CAS rats displayed no change in time spent in the center, but (C) a significant increase in time spent in the corners (p < 0.05). D Social interaction arena setup is depicted. E CAS did not impact SI ratio in either sex when assessed in adolescence or adulthood. F CAS led to a significant increase in time spent in opposite corners in males (p < 0.05), but not in females. Data are presented as mean ± SEM. CAS*, main effect of CAS (p < 0.05); *, effect of CAS (p < 0.05) within males; # main effect of sex. CAS Chronic Adolescent Stress, NS Non-stressed, SI social interaction.