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. 2021 Apr 28;8:643681. doi: 10.3389/fmolb.2021.643681

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Copyright © 2021 Khorkova, Hsiao and Wahlestedt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Novel biological mechanisms accessible through NBTs. (A) Modulation of splicing; SP: spliceosome components; ASO: antisense oligonucleotides. (B) Modulation of miRNA activity. (C) Small activating RNAs (saRNA). (D) Modulation of natural antisense transcript (NAT) activity; RNApol: RNA polymerase. (E) Extra-coding RNA (ecRNA); DNMT1: DNA methyl transferase 1. (F) Enhancer RNAs (eRNA); negative elongation factor complex (NELF); CBP: histone acetyltransferase CREB-binding protein.