Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Feb 18;31(4):383–394. doi: 10.1038/s41422-021-00474-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 2 — a Map and cartoon representations of the dimeric CaSR structure in the L-Trp-bound state (CaSR^Trp). The two subunits of CaSR are colored in cyan. L-Trp molecules are shown as yellow sticks. b Cartoon representation of a single VFT domain structure of CaSR^Trp. The density that was assigned to L-Trp is shown as mesh. c Superposition of the overall structures of CaSR^Trp and CaSR in the Icc conformation, indicating high structural similarity. d Structural superposition of single VFT domains derived from CaSR^Trp (blue) and CaSR^Icc (orange). The VFT domains from CaSR in both CaSR^Trp and CaSR^Icc reveal “closed” conformations. e Structural superimposition of single VFT domains in CaSR^Trp and CaSR^Ioo, showing the opening of the VFT in the Ioo conformation (gray) and the closure of the VFT in the CaSR^Trp (blue).