Fig. 6. Artesunate inhibits cell proliferation by inhibiting lysosomal function partly through ROS.
a DHE results showing the ROS level in the A549/TAX cells treated with artesunate for 24 h in the presence or absence of NAC. b LysoSensor results showing the effect of NAC on the A549/TAX cells treated with artesunate for 24 h. c Western blot detection of Cathepsin L in the cells treated with artesunate and TX. d CCK-8 results showing the effect of TX on the MCF-7/ADR cells treated with artesunate for 72 h. Values are presented as the means ± SD from three independent experiments. *P < 0.05, ***P < 0.001, and ns P > 0.05 versus the control group.