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. 2021 Apr 15;12:663325. doi: 10.3389/fphar.2021.663325

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Copyright © 2021 Wang, Ye, Xun, Mo, Tong, Ni, Huang, Liu, Zhan and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VRC metabolism by LPS with or without PSA treated rats and mice. (A) VRC plasma kinetics in individual rats (n = 5, respectively). (B) Pharmacokinetic (PK) parameters in rats. (C) VRC blood concentrations in individual mice (n = 5, respectively). (D) VRC liver tissue concentrations in individual mice. The PK parameters were calculated according to the noncompartmental PK calculated by DAS 2.0 software. Tmax, maximum time corresponding to Cmax; AUC (0-∞), area under the curve from 0 to ∞; MRT, Mean residence time; t1/2, half-life; Cmax, maximum concentration; Rats receiving a single dose of VRC, 10 mg/kg; Mice receiving a single dose of VRC, 10 mg/kg. (a) LPS vs. CON; (b) LPS + Germ free vs. LPS; (c) LPS + Germ free + PSA vs. LPS + Germ free. Unpaired t test, *p < 0.05, **p < 0.01, ***p < 0.001.