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. 2021 Apr 15;12:663325. doi: 10.3389/fphar.2021.663325

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Copyright © 2021 Wang, Ye, Xun, Mo, Tong, Ni, Huang, Liu, Zhan and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hepatic function and histological analysis of the livers after intravenous administration of LPS with or without PSA in mice. (A–C) Plasma chemistry profile analyses of aspartate transaminase (AST) (A) alanine transaminase (ALT) (B) and total bilirubin (C) after VRC treated 5 days (D) Left: Immunohistochemical (IHC) detection of hepatic IL-1β (200 × upper and 400 × down), Right: IL-1β expression intensity in different treated groups were analyzed (E) Left: Photomicrographs of stained with H&E (200×). Right: Semiquantitative pathology scores of liver tissues. *p < 0.05, **p < 0.01, ***p < 0.001; Unpaired t test.