Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Apr 15;12:663325. doi: 10.3389/fphar.2021.663325

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Wang, Ye, Xun, Mo, Tong, Ni, Huang, Liu, Zhan and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

PSA inhibits the secretion of IL-1β may through TLR4 signal pathway. (A) Optimum PSA concentration selection based on the mRNA expression levels of IL-1β. (B) mRNA levels of key toll-like recepters in the liver (n = 6–12). (C–G) Immunblots (C) and densitometric analysis of pro-IL-1β (D), IL-1β-p17 (E), CYP2C19 (F) and P-gp (G) in liver tissue homogenates treated with the vehicle, LPS and LPS + PSA. (G–K), Immunblots (H) of key proteins of TLR4 signal transduction and densitometric analysis of these proteins (I–L) in primary hepatocyte treated with the vehicle, LPS, LPS + PSA and LPS + TAK-242. Western blot results are representative of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, Unpaired t test.