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. 2021 Apr 15;12:663325. doi: 10.3389/fphar.2021.663325

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Copyright © 2021 Wang, Ye, Xun, Mo, Tong, Ni, Huang, Liu, Zhan and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PSA up-regulates the expression of hepatic CYP2C19 and P-gp by inhibiting TLR4/NF-κB signal pathway. (A,B) RT-PCR and Western blot analyses were used to evaluate the efficiency of TLR4 knock-down by siRNA (**p < 0.01) (C–H) Immunblots (C) and densitometric analysis of TLR4 (D), MyD88 (E), TRAF6 (F), NF-κB (G) and IL-1β (H) in primary hepatocytes treated with the vehicle, LPS, LPS + siTLR4 and LPS + PSA (C,I–J), Immunblots (C) and densitometric analysis of CYP2C19 (I), and P-gp (J) in primary hepatocytes. Western blot results represent three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001, t-test.