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Schematic illustration of PSA regulatory mechanism of VRC metabolism. PSA inhibits the TLR4/NF-κB axis signal transduction pathway induced by LPS, suppressed the secretion of mature IL-1β in the cytoplasm, promotes the expression of liver drug metabolic enzyme (CYP2C19) and transporter (P-gp and its protein coding gene ABCB1), and finally improves the metabolic ability of voriconazole.
