Table 2.
Age-adjusted Cox regression analysis for predicting osteoporosis in the unmatched (A) and matched (B) cohorts.
| Variables | Univariable analysis | Age-adjusted Cox regression analysis | |||||||
|---|---|---|---|---|---|---|---|---|---|
| ADT | Duration of ADT | ||||||||
| HR (95% CIs) | p-value | HR (95% CIs) | p-value | HR (95% CIs) | Pairwise comparison p-value | ||||
| (A) Unmatched cohorts | |||||||||
| Age | 1.065 (1.062–1.067) | < 0.0001 | 1.059 (1.057–1.062) | < 0.0001 | 1.059 (1.056–1.062) | < 0.0001 | |||
| ADT | |||||||||
| No | Ref. | Ref. | |||||||
| Yes | 2.112 (2.018–2.211) | < 0.0001 | 1.377 (1.312–1.445) | < 0.0001 | |||||
| Duration of ADT | |||||||||
| No | Ref. | Ref. | Ref. | ||||||
| < 1 year | 1.493 (1.356–1.644) | < 0.0001 | 1.043 (0.947–1.150) | 0.3921 | Ref. | ||||
| 1–2 years | 2.038 (1.861–2.232) | < 0.0001 | 1.305 (1.190–1.432) | < 0.0001 | 0.0006 | Ref. | |||
| 2–3 years | 2.088 (1.900–2.295) | < 0.0001 | 1.362 (1.237–1.498) | < 0.0001 | < 0.0001 | 0.51 | Ref. | ||
| > 3 years | 2.514 (2.367–2.671) | < 0.0001 | 1.599 (1.502–1.702) | < 0.0001 | < 0.0001 | 0.0001 | 0.003 | ||
| (B) Matched cohorts | |||||||||
| Age | 1.036 (1.032–1.040) | < 0.0001 | 1.035 (1.031–1.039) | < 0.0001 | 1.034 (1.031–1.038) | < 0.0001 | |||
| ADT | |||||||||
| No | Ref. | Ref. | |||||||
| Yes | 1.392 (1.315–1.473) | < 0.0001 | 1.381 (1.305–1.461) | < 0.0001 | |||||
| Duration of ADT | |||||||||
| No | Ref. | Ref. | Ref. | ||||||
| < 1 year | 0.982 (0.887–1.088) | 0.7334 | 1.016 (0.917–1.125) | 0.762 | Ref. | ||||
| 1–2 years | 1.317 (1.195–1.452) | < 0.0001 | 1.293 (1.173–1.426) | < 0.0001 | 0.0002 | Ref. | |||
| 2–3 years | 1.363 (1.232–1.507) | < 0.0001 | 1.352 (1.222–1.495) | < 0.0001 | < 0.0001 | 0.5174 | Ref. | ||
| > 3 years | 1.681 (1.568–1.801) | < 0.0001 | 1.639 (1.529–1.757) | < 0.0001 | < 0.0001 | < 0.0001 | 0.003 | ||
ADT androgen deprivation therapy, CI confidence interval, HR hazard ratio.