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. 2021 May 12;11:9749. doi: 10.1038/s41598-021-88870-9

Figure 7.

Figure 7

The c-9, t-11-CLA-LPC level in the brain was increased by the c-9, t-11-CLA diet. The LPC peaks in the various brain regions and the liver were detected with LC–MS/MS analysis. Relative abundance is shown as the area ratio per tissue weight (g) (left panel), and the fold change was indicated as the relative ratio of the peak area in c-9, t-11-CLA diet-fed mice to that in control diet-fed mice (right panel). The peak of sn-1-c-9, t-11-CLA-LPC in the lysates of the cortex (P = 0.00068) (A), cerebellum (P = 0.0017) (C), olfactory bulb (P = 0.04) (D) and brain stem (P = 0.015) (E) was significantly increased in c-9, t-11-CLA diet-fed mice as well as in the liver (P = 0.0025) (F). The peak for sn-1-c-9, t-11-CLA-LPC in the hippocampus (P = 0.09) was not significantly changed, but it tended to be increased. A peak with no significant change in area for LA [sn-1-(and also sn-2-CLA-) and sn-2-LA]-LPC was observed between brain regions from c-9, t-11-CLA diet-fed and control diet-fed mice, but an increased tendency by the c-9, t-11-CLA diet was observed. In the liver, the peak of sn-1-LA-LPC and also sn-2-CLA-LPC was significantly increased by the c-9, t-11-CLA diet. Left panel: LPC area ratio/g tissue. n = 4 mice for each group. *P < 0.05, **P < 0.001, ***P < 0.0001 ns: not significant.