Table 8.

ADME properties of 6 compounds as predicted by preADMET and pkCSM.

Compound ID	Absorption			Distribution		Metabolism				Excretion
	HIA	Caco2	MDCK	PPB	BBB	CYP2C19	CYP2C9	CYP3A4	CYP2D6	log(CLtot) (log ml/min/kg)	Renal OCT2
91 (CCR)	90.44	19.40	56.30	61.89	1.48	N	I	N	N	1.064	No
3	91.45	38.05	56.08	85.74	3.21	N	N	N	N	0.938	No
88	94.69	20.78	45.34	87.97	0.61	N	I	I	N	1.074	No
EF31 (CL)	95.99	44.79	32.46	54.10	0.08	N	N	N	N	0.816	No
UBS109	97.53	55.56	42.13	58.73	0.53	N	N	N	N	0.682	No
Bisacurone	90.98	24.61	321.05	88.34	0.45	I	I	N	N	1.382	No

CCR Curcuma caesia Roxb., CL Curcuma longa L., HIA human intestinal absorption, MDCK madin-darby canine kidney, PPB plasma protein binding, BBB blood brain barrier, CYP cytochrome P450, N non inhibitor, I inhibitor, CL_tot total clearance, OCT2 organic cation transporter 2.

Bold Compound 3 with favourable ADME properties.