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. 2021 Jan 7;42(4):648–654. doi: 10.1038/s41401-020-00577-1

Fig. 2. Osimertinib-resistant cells show deficiency in DNA damage repair.

Fig. 2

a Western blot analysis of γH2AX and p-EGFR (Tyr1068) in H1975-S and H1975-OR cells treated with cisplatin at the indicated doses for 24 h. b Western blot analysis of γH2AX and p-EGFR (Tyr1068) in H1975-S and H1975-OR cells treated with cisplatin at the indicated time points. c Analysis of DNA comet tails by alkaline comet assay in H1975-S and H1975-OR cells treated with 5 µM cisplatin for 24 h and then released from cisplatin for 24 h to allow DNA repair.