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. 2020 Nov 23;46(6):1183–1193. doi: 10.1038/s41386-020-00912-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Schematic illustration showing the center of the microinjection sites within the prelimbic cortex for vehicle and RU 486. b Bilateral microinjections of the glucocorticoid receptor antagonist RU 486 in the prelimbic cortex enhance writhing behavior in mice tested in stranger dyads (n = 9) when compared with vehicle-injected stranger dyads (n = 7), and mice tested alone, both vehicle-injected (n = 8) and RU 486-injected (n = 7) (two-way ANOVA, main effect of social context: F_1,27 = 6.37, p = 0.02; social context × drug interaction: F_1,27 = 4.67, p < 0.05). c Bilateral microinjections of RU 486 within the anterior cingulate cortex do not enhance writhing behavior in stranger dyads (n = 5) when compared with vehicle-injected stranger dyads (n = 5) (t₈ = 0.3, p = 0.77). d Schematic illustration showing the center of the microinjection sites within the prelimbic cortex for vehicle and corticosterone. e Bilateral microinjections of the glucocorticoid receptor agonist corticosterone in the prelimbic cortex, decreased writhing behavior in mice tested in cagemate dyads (n = 7) when compared with vehicle-injected cagemate dyads (n = 8) and mice tested alone, both vehicle-injected (n = 8, replotted from b) and corticosterone-injected (n = 6) (two-way ANOVA, main effect of drug: F_1,24 = 4.96, p < 0.05; social context × drug interaction: F_1,24 = 4.3, p < 0.05). *p < 0.05.