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A 7-year-old boy with sickle cell disease who presented with dyspnea and chest pain tested positive for SARS-CoV-2. The patient was unresponsive, having desaturations and being intubated. Brain MR imaging showed T2-FLAIR hyperintensity and cortical edema in the occipital lobes, consistent with posterior reversible encephalopathy syndrome, partially resolving on subsequent imaging (A–C, arrows). Note interval evolution of right frontal subarachnoid hemorrhage (D–F, arrows).
