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. 2021 Apr 5;77(6):2004–2013. doi: 10.1161/HYPERTENSIONAHA.120.16534

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© 2021 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Figure 2. — Nonlinear Mendelian randomization considering genetically proxied diastolic blood pressure (DBP) and incident cardiovascular outcomes. Nonlinear Mendelian randomization considering genetically proxied diastolic blood pressure (DBP) and incident cardiovascular outcomes: (A) all incident cardiovascular disease (CVD) events, (B) incident coronary artery disease (CAD), and (C) incident stroke. Displayed on the x axis are DBP values in mm Hg. The y axis shows the hazard ratio for the respective incident cardiovascular event. Reference is set to a population mean DBP value of 81.8 mm Hg. Gray lines depict the 95% CI.