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. 2021 Apr 5;77(6):2004–2013. doi: 10.1161/HYPERTENSIONAHA.120.16534

Figure 3.

Figure 3.

Nonlinear Mendelian randomization considering genetically proxied systolic blood pressure (SBP) and incident cardiovascular outcomes split by sex. Nonlinear Mendelian randomization considering genetically proxied systolic blood pressure (SBP) and incident cardiovascular outcomes split by sex: (A) all incident cardiovascular disease (CVD) events in men, (B) incident coronary artery disease (CAD) in males, and (C) incident stroke in men. D–F, Equivalent analyses in women. Displayed on the x axis are SBP values in mm Hg. The y axis shows the hazard ratio for the respective incident cardiovascular event. Reference is set to a mean SBP value of 136.5 mm Hg. Gray lines depict the 95% CI.