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. 2020 Sep 12;46(5):882–890. doi: 10.1038/s41386-020-00826-1

Fig. 1. Leuprolide increases locomotion and changes social preference in male mice, but not female mice.

Fig. 1

a Timeline of leuprolide administration and behavioral testing. b Leuprolide increased total distance traveled in the OF in male mice. c Leuprolide did not increase the distance traveled in the OF in female mice. d During the 1st trial of the SI assay, all mice investigated the empty male zone equally. e During the 1st trial of the SI assay, all mice investigated the empty female zone equally. f During the 2nd trial of the SI assay, leuprolide-treated male mice spent more time in the male zone when compared with saline-treated male mice. Leuprolide treatment did not impact social preference of female mice. g During the 2nd trial of the SI assay, leuprolide-treated male mice spent less time in the female zone when compared with saline-treated male mice. Leuprolide treatment did not impact social preference of female mice. n = 9–10 mice per group. Error bars represent ± SEM. *p < 0.05; **p < 0.01. min minutes, sec seconds, OF open field test, SI social interaction test.