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. 2021 May 12;7:52. doi: 10.1038/s41523-021-00255-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a NTHL1 expression in sporadic breast cancer and NTHL1-het cancer of ER+, HER2+, and triple-negative types. Multiplex immunofluorescent staining approach was used and the fluorescence signal was displayed in colorimetric pattern for better contrast. NTHL1: brown color; DIPI: blue color. The epithelial marker AE1/AE3 (Supplementary Fig. 4) was used to identify cancer cells in the breast cancer tissue in NTHL1 expression quantitation in (b) and (c). Scale bar = 100 μm. b The average intensity of NTHL1 in sporadic cancer group compared to NTHL1-het group. c The average intensity of NTHL1 in sporadic cancer group compared to NTHL1-het group according to ER, PR, and HER2 status. BC breast cancer, TNBC triple-negative breast cancer.