Table 2.

Incidence of other cancers in NTHL1 families compared to non-NTHL1 families in BEACCON study.

Family history^a	NTHL1 families^b n = 22		Non-NTHL1 families^c n = 3239		OR	95% CI	p Value
Family history^a	Cancer (%)	Non-cancer	Cancer (%)	Non-cancer	OR	95% CI	p Value
Breast cancer	28 (6.93)	376	3929 (6.46)	56,872	1.08	0.71–1.59	0.68
Male breast cancer	1 (0.25)	403	77 (0.13)	60,724	1.96	0.05–11.29	0.40
Colorectal cancer	9 (2.23)	395	1559 (2.56)	59,242	0.87	0.39–1.66	0.87
Ovarian cancer	6 (1.49)	398	541 (0.89)	60,260	1.68	0.61–3.71	0.18

^aCancer affected family members in the first and second degree of relatives of index cases.

^bNTHL1 families, families in which the index cases carry a germline monoallelic LoF variant in NTHL1.

^cNon-NTHL1 families, families in which the index cases do not carry any LoF variants in NTHL1.