Table 1.
Frequent regions affected by cnLOH in SCRC cases: (A) Four SCRC groups and (B) Two SCRC groups.
| (A) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Chromosome | Cytoband start | Cytoband end | SCRC | MM SCRC | MP SCRC | PM SCRC | PP SCRC | p valuea |
| 16 | p11.2 | p11.1 | 44 (59.5) | 10 (62.5) | 12 (75.0) | 12 (50.0) | 10 (55.6) | NS |
| 11 | p11.2 | p11.12 | 21 (28.4) | 5 (31.3) | 3 (18.8) | 5 (20.8) | 8 (44.4) | NS |
| 2 | q11.1 | q11.2 | 11 (14.9) | 1 (6.3) | 3 (18.8) | 2 (8.3) | 5 (27.8) | NS |
| 10 | q22.1 | q22.2 | 11 (14.9) | 4 (25.0) | 1 (6.3) | 4 (16.7) | 2 (11.1) | NS |
| 8 | q11.1 | q23.3 | 10 (13.5) | 2 (12.5) | 5 (31.3) | 3 (12.5) | – | NS |
| 6 | p22.1 | p21.32 | 9 (12.2) | – | 1 (6.25) | 6 (25.0) | 2 (11.1) | NS |
| 7 | q11.21 | q11.22 | 9 (12.2) | 4 (25.0) | – | 3 (12.5) | 2 (11.1) | NS |
| 4 | q24 | q35.2 | 7 (9.5) | 2 (12.5) | – | 3 (12.5) | 2 (11.1) | NS |
| 5 | q34 | q35.3 | 7 (9.5) | 1 (6.3) | 3 (18.8) | 2 (8.3) | 1 (5.6) | NS |
| 8 | p23.1 | p11.1 | 7 (9.5) | 2 (15.5) | 3 (18.8) | 2 (8.3) | – | NS |
| 10 | p12.31 | p12.1 | 7 (9.5) | 2 (12.5) | 3 (18.8) | 1 (4.2) | 1 (5.6) | NS |
| (B) | ||||||||
| Chromosome | Cytoband start | Cytoband end | SCRC | Monoclonal | Polyclonal | p valuea | ||
| 16 | p11.2 | p11.1 | 44 (59.5) | 22 (68.8) | 22 (52.4) | NS | ||
| 11 | p11.2 | p11.12 | 21 (28.4) | 8 (25.0) | 13 (31.0) | NS | ||
| 2 | q11.1 | q11.2 | 11 (14.9) | 4 (12.5) | 7 (16.7) | NS | ||
| 10 | q22.1 | q22.2 | 11 (14.9) | 5 (15.6) | 6 (14.3) | NS | ||
| 8 | q11.1 | q23.3 | 10 (13.5) | 7 (21.9) | 3 (7.1) | NS | ||
| 6 | p22.1 | p21.32 | 9 (12.2) | 1 (3.1) | 8 (19.0) | 0.038 | ||
| 7 | q11.21 | q11.22 | 9 (12.2) | 4 (12.5) | 5 (11.9) | NS | ||
| 4 | q24 | q35.2 | 7 (9.5) | 2 (6.3) | 5 (11.9) | NS | ||
| 5 | q34 | q35.3 | 7 (9.5) | 4 (12.5) | 3 (7.1) | NS | ||
| 8 | p23.1 | p11.1 | 7 (9.5) | 5 (15.6) | 2 (4.8) | NS | ||
| 10 | p12.31 | p12.1 | 7 (9.5) | 5 (15.6) | 2 (4.8) | NS | ||
aStatistical analysis was performed by Pearson’s Chi square (χ2) test. Parentheses refer to percentage numbers. cnLOH copy-number-neutral loss of heterozygosity, SCRC synchronous colorectal cancer, MM monoclonal monosegmental, MP monoclonal pancolonic, PM polyclonal monosegmental, PP polyclonal pancolonic.