. 2021 Jan 26;46(5):928–938. doi: 10.1038/s41386-021-00971-1

Table 2.

Brain regions showing significant differences in white matter FA between HCMV+ participants with MDD and HCMV− participants with MDD.

	Region	Sample	t-value^a	Voxel^b (mm³)	MNI coordinates^c
	Region	Sample	t-value^a	Voxel^b (mm³)	X	Y	Z
ROI analysis (P_FWE < 0.05)	R. IFOF	Discovery	−3.75	1316	−36	+13	−4
		Replication	−3.13	1316	−34	+20	−1
Whole-brain analysis (P_uncorrected < 0.05)	R. IFOF	Discovery	−3.75	3913	−36	+13	−4
		Replication	−3.41	4421	−36	+20	−14
	L. IFOF	Discovery	−3.64	3545	+51	+26	+2
		Replication	−4.41	2274	+48	+22	−6

HCMV human cytomegalovirus, HCMV− human cytomegalovirus seronegative, HCMV+ human cytomegalovirus seropositive, ROI region of interest, FWE family-wise error rate, R.IFOF right inferior fronto-occipital fasciculus, L.IFOF left inferior fronto-occipital fasciculus, MNI Montreal Neurological Institute.

^aBi-sided cluster peak t-value is shown; A negative value indicates that HCMV+ participants have lower FA than HCMV− participants.

^bClustering method was faces or edges touch.

^cCluster peak MNI coordinates are shown. The X, Y, Z dimensions refer to left (+) to right (−), posterior (+) to anterior (−), and inferior (+) to superior (−).