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. 2021 May 12;11:10109. doi: 10.1038/s41598-021-89586-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Different pathological properties of prions in N2aC24(R1) cells from RML and 22L prions. (a) The percentage of symptom-free mice after the 1st intracerebral inoculation with brain homogenates from N2aC24(R1) cell lysate-inoculated, terminally ill mice, the 2nd intracerebral inoculation with brain homogenates from terminally ill mice firstly inoculated with N2aC24(R1)-infected mouse brain homogenates, and intracerebral inoculation with RML- or 22L-infected mouse brain homogenates. (b) HE staining of the brains of terminally ill mice in (a). Bars, 100 μm. (c) Vacuole counts at different brain areas of terminally ill mice [5 fields in each brain area from each mouse group (n = 3)] in (b). Cx, cerebral cortex; Hp, hippocampus; Th, thalamus; Cb, cerebellum. Error bars, standard deviation.