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. 2021 May 12;12:2735. doi: 10.1038/s41467-021-23045-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A A sample cryo-electron micrograph of the AIM2^PYD filament (total 976 micrographs were taken). B An average power spectrum of the AIM2^PYD filament from 512 px-long nonoverlapping segments. C The AIM2^PYD filament model built into the EM map. A subunit with visible side chains is shown. D The model of AIM2^PYD filament. Each subunit is colored differently. E A cartoon representation of three unique filament interface types. Side chains at each filament interface are shown as a stick configuration. F Overlays between AIM2^PYD and ASC^PYD (PDB ID: 3J63) filaments.