TABLE 5.
Associations between genetic polymorphisms and the changes in ocular biometric parameters in various genetic models.
| Marker | Polymorphisms | N (%) | ΔAL (mm) | P | P’ | ΔAL/CRC | P | P’ |
| rs10760673 (TGFBR1) | ||||||||
| Dominant | GG | 163 (36.30) | 0.94 (0.65, 1.32) | 0.14 (0.11, 0.19) | ||||
| GA or AA | 180 (63.70) | 1.04 (0.71, 1.37) | 0.046* | 0.047* | 0.15 (0.11, 0.21) | 0.136 | 0.139 | |
| Recessive | GG or GA | 272 (82.90) | 0.94 (0.66, 1.31) | 0.14 (0.11, 0.19) | ||||
| AA | 71 (17.10) | 1.11 (0.75, 1.57) | 0.027* | 0.027* | 0.17 (0.11, 0.23) | 0.034* | 0.029* | |
| Additive | – | – | – | 0.011* | 0.013* | – | 0.032* | 0.031* |
| rs7550232 (TGFB2-AS1) | ||||||||
| Dominant | AA | 380 (85.60) | 1.01 (0.68, 1.40) | 0.15 (0.11, 0.20) | ||||
| AC or CC | 64 (14.40) | 1.19 (0.71, 1.37) | 0.188 | 0.184 | 0.17 (0.12, 0.21) | 0.392 | 0.386 | |
| Recessive | AA or AC | 443 (99.80) | 0.98 (0.67, 1.39) | 0.15 (0.11, 0.20) | ||||
| CC | 1 (0.20) | 0.92 (0.92, 0.92) | 0.716 | 0.752 | 0.11 (0.11, 0.11) | 0.472 | 0.474 | |
| Additive | – | – | – | 0.223 | 0.223 | – | 0.472 | 0.473 |
AL, axial length; CRC, corneal radius of curvature; Δ is the change in AL or AL/CRC during 3.5-year follow-up; P, P-value; P’, P-value adjusted by 10,000 permutations. Adjusted for gender, age, near work time, and outdoor time. *Statistically significant at P < 0.05.