a. Clinical data for the case-control study to assess plasma biomarkers of vascular invasion. b. Plasma levels of FN1, AFP, VEGFR2 and PAI-1 in patients with HCC compared to cirrhosis-alone. c. ROC curves for the diagnosis of HCC of FN1, AFP, combined FN1+AFP, VEGFR2 and PAI-1. d. Correlation of plasma fibronectin levels with HCC tumor focality, tumor stage, etiology of cirrhosis and vascular invasion. * p<0.05; **p<0.01; ***p<0.001.