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. 2021 Apr 30;17(4):e1009537. doi: 10.1371/journal.ppat.1009537

Fig 2. The Kp ter operon is not exclusive to hypervirulence plasmids.

Fig 2

ter+ plasmids from Martin et al. mSystems, 2018 [10] (A-C) and reference strains from the NCBI database (D-F) were analyzed. (A,D) Relative frequencies of sequence types (ST) of Kp strains containing ter+ plasmids. HvKp sequence types previously associated with the ter operon are outlined in a dashed line. (B,E) Heat map of ter+ plasmid sequence similarity to genes known to influence infection and antibiotic resistance genes. Each row represents an individual plasmid in the order of S2 Table (Martin et al. mSystems, 2018 [10] index 1–14, NCBI reference strains index 15–102). The pK2044 hvKp plasmid is highlighted by the red box, and hypervirulent Kp sequence types (hvST) previously associated with the ter operon are indicated. (C,F) To determine if any neighboring gene was consistently associated with ter, the gene neighborhood of ter plasmids encoding the ter operon from Martin et al. mSystems, 2018 [10] was visualized (C) and the frequency of ORFs adjacent to the ter operon encoded on reference plasmids from the NCBI database was calculated (F).