Table 2. Putative markers of exposure to sporozoites.
Genes selected by the greedy method to cover all volunteers with their gene ID, function and number of volunteers with antibodies after CPS immunization as reported by Obiero et al. [13]. The non-synonymous SNPs are given as a proxy for genetic variability, with PlasmoDB and two sequenced laboratory strains as reference.
| Gene ID | function | No. (%) of volunteers with antibodies | Non-syn SNP/kb PlasmoDB | Non-syn SNPs | |
|---|---|---|---|---|---|
| NF135 | NF166 | ||||
| PF3D7_0630600 | Conserved hyp | 20 (52.6) | 2.8 | 0 | 1 |
| PF3D7_0906500 | Arginase | 19 (50.0) | 6.5 | 1 | 1 |
| PF3D7_1456700 | Conserved hyp. | 19 (50.0) | 2.9 | 0 | 0 |
| PF3D7_0719700 | 40S ribosomal S10 | 15 (39.5) | 0 | 0 | 0 |
| PF3D7_1219100 | Clathrin heavy chain | 12 (31.6) | 5.5 | 0 | 2 |
| PF3D7_0301700 | Hypothetical exp. | 10 (26.3) | 6.3 | 0 | 1 |
| PF3D7_1122700 | Conserved hyp. | 9 (23.7) | 7.8 | 0 | 0 |
| PF3D7_1455800 | LCCL prot. | 6 (15.8) | 4.1 | 0 | 0 |