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. 2021 Apr 28;134(9):1009–1013. doi: 10.1097/CM9.0000000000001498
Breast cancer follow-up Level of evidence Recommendation strength
6.1 Interval for follow-up
 6.1.1 1–4 times per year within 5 years of surgery[12] II A
 6.1.2 Annually after 5 years of surgery[12] II A
6.2 Content of follow-up
 6.2.1 Loco-regional recurrence
a. Ultrasound[12] II A
b. Mammography[12,29] I A
 6.2.2 Distant metastasis
a. Screening of distant metastases is not recommended for asymptomatic patients[30,31] I A
b. Tumor markers III C
c. CT of chest III C
d. CT/ ultrasound/MRI of abdomen III C
e. Bone scan III C
f. FDG PET/CT III C
 6.2.3 Complication of surgery
Lymphedema[12] II A
 6.2.4 Complication of medication
a. Endometrial evaluation during treatment of tamoxifen[12] II A
b. Assessment of bone mineral density during treatment of aromatase inhibitor[12] II A
 6.2.5 Guidance of a healthy lifestyle[12] II A

CT: Computed tomography; FDG PET: 18F-deoxyglucose positron emission tomography; MRI: Magnetic resonance imaging.