Figure 5. Contingency reversal learning in home-cage.

(A) Mice discriminate the location of a pole (anterior or posterior) and report the location using directional licking (left or right) without a delay epoch. The task switches between standard sensorimotor contingency and reversed contingency once mice reach criterion performance. Criterion performance, >80% for 100 trials. (B) Behavioral performance data from two example mice. Bin size, 50 trials. Blue line, contingency reversals. Dashed line, 70% correct. (C) The number of trials to acquire new contingencies over multiple contingency reversals. The number of trials to reach criterion performance is normalized to the first contingency reversal. Individual lines show individual mice. (D) The number of trials needed to learn the tactile decision task vs. the average number of trials to reach criterion performance in contingency reversal learning. Task learning is from the start of head-fixation training to reaching criterion performance. Individual dots show individual mice. Line, linear regression. Two mice from (C) were excluded because they previously learned a different behavioral task.