Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 4;8(3):ENEURO.0055-20.2021. doi: 10.1523/ENEURO.0055-20.2021

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Parga Becerra et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

PMC Copyright notice

Figure 3. — Dose dependence of CCI effects on THIP-induced tonic currents. A, Membrane currents from a sham-treated cell before and during bath application of increasing concentrations of THIP. Right hand panel shows time course of tonic current change for this experiment. B, Membrane currents from a CCI-ipsi cell before and during bath application of THIP, right hand panel shows time course of current change for this experiment. C, Dose–response relationship for THIP-activation of tonic currents in control and CCI-ipsi DGGCs. Data points represent mean ± SEM. CCI reduced current amplitudes with THIP concentrations >3 μm. Solid line is a Hill equation fit to data, the estimated EC₅₀ was 4.9 and 2.5 μm for control and CCI-ipsi cells, respectively. D, Normalized dose response data from C. Data and fitted curves were normalized to maximum value (I_max) for these fits to better illustrate the similar EC₅₀ values. Error bars are omitted for clarity. *p < 0.05, **p < 0.01.