Figure 5.

CCI reduces frequency, but not amplitude or kinetics, of sIPSCs in CCI-ipsilateral cells. A, Membrane currents from control and CCI-ipsi DGGCs (2 min of gap-free recording at −70 mV). B, Data from A on expanded timescale. Reduced frequency of sIPSCs in CCI-ipsi cells is visibly apparent two weeks after CCI. C, Average sIPSC from control and CCI-ipsi DGGCs. Average sIPSCs were normalized to allow comparison of time course and decay kinetics, which were indistinguishable between control and CCI-ipsi cells. D, Mean (±SEM) for sIPSC parameters in control and CCI cells. CCI significantly decreased sIPSC frequency by 59%, but sIPSC amplitude, rise time, decay time constant, and total charge transfer were not significantly affected. Circles represent data from individual cells of control (black) or CCI-treated (red) animals. n.s., not significant. **p < 0.01.