Figure 1.

Study development. On day one, we received the animals at approximately 100 g. Since then, they started to received their respective chow. When they reached a weight between 250 g and 300 g, we performed the first echocardiogram and intraperitoneal injection of DOX or saline solution according to which group the animals belonged to. On the thirty-fifth day, at forty-eight hours after administering the DOX or saline solution, we euthanized the animals and collected the blood and cardiac samples for analysis.