Table 6.
Matrix metalloproteinase (MMP-2) activation in myocardial tissue forty-eight hours after injection of doxorubicin.
| C (n = 6) | GT (n = 6) | D (n = 6) | DGT (n = 6) | P i | P gt | P d | |
|---|---|---|---|---|---|---|---|
| MMP-2at | 9412 ± 6060 | 7690 ± 3939 | 11413 ± 10306 | 8468 ± 12171 | 0,85 | 0,49 | 0,68 |
| MMP-2int. | 21907 ± 10304 | 23576 ± 11532 | 54553 ± 26211 | 32163 ± 32206 | 0,16 | 0,23 | 0,02 |
| MMP-2inat | 35800 ± 21485 | 34116 ± 32446 | 48421 ± 29076 | 48677 ± 32498 | 0,93 | 0,95 | 0,24 |
| MMP-2at/inat | 2, 41 ± 0, 62 | 1, 14 ± 0, 74 | 1, 94 ± 1, 76 | 1, 11 ± 1, 80 | 0,81 | 0,79 | 0,72 |
| MMP-2int/inat | 0, 89 ± 0, 62 | 0, 86 ± 0, 43 | 1, 94 ± 1, 58 | 0, 57 ± 0, 21 | 0,09 | 0,13 | 0,53 |
Groups: C: control; GT: green tea; D: doxorubicin; DGT: doxorubicin+green tea. MMP-2a: active matrix metalloproteinase; MMP-2int: intermediary matrix metalloproteinase; MMP-2inat: inactive matrix metalloproteinase. Values are expressed in mean ± standard deviation. P value: two-way ANOVA. Pi: P value of interaction; Pgt: P value of green tea; Pd: P value of doxorubicin. When we observed the interaction between factors (Pi < 0, 05), we compared the groups. MMP-2int: D ≠ C, D ≠ GT, DGT ≠ C, and DGT ≠ GT.