. 2020 Jun 6;11(2):210–219. doi: 10.1016/j.jpha.2020.05.014

Table 1.

MIC, FIC and FIC indices of LNA and MPM against KPC-KP cells.

Antimicrobial agents	KPC-KP				Type of interaction
Antimicrobial agents	MIC_O	FIC	FICI	FICI_c	Type of interaction
LNA (%, V/V)	2.5	1.25	0.50	1.00	Additive
MPM (μg/mL)	32	16	0.50	1.00	Additive

MIC: minimum inhibitory concentration; FIC: fractional inhibitory concentration; LNA: linalyl anthranilate; MPM: meropenem; KPC-KP: carbapenemase-producing Klebsiella pneumoniae. MIC_O: MIC of one component alone; FIC: MIC of one component in the most effective combination; FICI_C_: total FICI of the combination of both samples. FICI_c ≤0.5: synergistic; FICI_c >0.5–4.0: additive; FICI_c >4.0: antagonistic.