Table 3.
Changes from baseline to end of treatment in fecal bile acid profiles
| Mean ± SD | ||||
|---|---|---|---|---|
| Bile acid (nmol/g) | Day 0 | Day 28 | Delta (day 28–day 0) | P-values |
| Unconjugated primary BAs | 14,991 ± 23,075 | 5645 ± 8425 | −9345 ± 23,352 | 0.295 |
| CA | 8587 ± 12,850 | 3777 ± 6122 | −4809 ± 13,268 | 0.339 |
| CDCA | 6405 ± 10,250 | 1868 ± 2481 | −4536 ± 10,302 | 0.253 |
| Unconjugated secondary BAs | 101,956 ± 95,530 | 62,217 ± 35,861 | −39,738 ± 84,682 | 0.226 |
| DCA | 60,510 ± 54,809 | 34,570 ± 22,537 | −25,940 ± 49,197 | 0.180 |
| LCA | 37,583 ± 45,774 | 26,183 ± 15,718 | −11,400 ± 38,185 | 0.426 |
| UDCA | 3864 ± 5595 | 1466 ± 3013 | −2398 ± 3836 | 0.120 |
| Primary to secondary ratio | 0.81 ± 1.95 | 0.16 ± 0.27 | −0.65 ± 1.70 | 0.314 |
| Total BAs | 118,447 ± 92,312 | 68,742 ± 40,009 | −49,706 ± 87,217 | 0.151 |
| Conjugated primary BAs | 1004.7 ± 774.8 | 455.2 ± 282.5 | −549.5 ± 660.7 | 0.051 |
| GCA | 320.7 ± 386.5 | 151.6 ± 127.2 | −169.2 ± 305.1 | 0.161 |
| TCA | 179.6 ± 293.7 | 56.6 ± 44.5 | −123.0 ± 294.1 | 0.275 |
| Total conjugated CA | 500.4 ± 458.8 | 208.15 ± 156.7 | −292.2 ± 395.3 | 0.075 |
| GCDCA | 380.6 ± 314.7 | 180.2 ± 104.6 | −200.4 ± 266.0 | 0.070 |
| TCDCA | 123.7 ± 87.8 | 66.9 ± 32.6 | −56.9 ± 82.6 | 0.093 |
| Total conjugated CDCA | 504.3 ± 350.3 | 247 ± 132.3 | −257.3 ± 305.8 | 0.049 |
| Conjugated secondary BAs | 569.6 ± 437.5 | 478.8 ± 280.8 | −90.8 ± 352.1 | 0.489 |
| GDCA | 405.4 ± 369.2 | 293.0 ± 188.6 | −112.4 ± 288.0 | 0.306 |
| TDCA | 46.9 ± 57.3 | 63.4 ± 79.0 | 16.5 ± 29.2 | 0.153 |
| Total conjugated DCA | 452.3 ± 386.6 | 356.4 ± 216.2 | −95.9 ± 305.1 | 0.404 |
| GLCA | 33.8 ± 61.5 | 47.2 ± 42.8 | 13.4 ± 34.7 | 0.312 |
| TLCA | 8.4 ± 16.7 | 19.0 ± 26.4 | 10.6 ± 12.6 | 0.049 |
| Total conjugated LCA | 42.2 ± 59.9 | 66.2 ± 51.0 | 24.0 ± 42.4 | 0.154 |
| GUDCA | 47.4 ± 45.0 | 25.2 ± 39.3 | −22.1 ± 39.6 | 0.158 |
| TUDCA | 27.7 ± 16.5 | 31.0 ± 35.7 | 3.3 ± 27.7 | 0.750 |
| Total conjugated UDCA | 75.1 ± 56.6 | 56.2 ± 74.1 | 18.9 ± 62.6 | 0.422 |
BA bile acid, CA cholic acid, CDCA chenodeoxycholic acid, DCA deoxycholic acid, GCA glyco-cholic acid, GCDCA glycol-chenodeoxycholic acid, GDCA glycol-deoxycholic acid, GLCA glycol-lithocholic acid, GUDCA glycol-ursodeoxycholic acid, LCA lithocholic acid, TCA tauro-cholic acid, TCDCA tauro-chenodeoxycholic acid, TDCA tauro-deoxycholic acid, TLCA tauro-lithocholic acid, TUDCA tauro-ursodeoxycholic acid, UDCA ursodeoxycholic acid