Table 1.

Pattern of infection for the different genotypes of HEV,

adapted from Centers for Disease Control and Prevention (2020)

Genotype	Transmission in humans?	Transmission routes	Geographical distribution pattern	Extrahepatic manifestations	Age groups at higher risk	Gender more commonly affected	Lethality
1	Yes	Faecal-oral; waterborne; blood transfusion; organ donation	Economically developed and developing countries	Pancreatic	Differs by countrya,b	Differs by countrya,b	0.5–1%c; 20% in pregnant womend,e,f
2	Yes	Faecal-oral; waterborne; blood transfusion; organ donation	Economically developing countries	Unknown	Young adults	Unknown	0.5–1%c
3	Yes	Foodborne; blood transfusion; organ donation	Economically developed and developing countries	Chronic infections in immune-compromised patients. Neurological, haematological, immunological and renal manifestationsg	Older adults (> 40 years)	Males	0.5–1%c
4	Yes	Foodborne; blood transfusion; organ donation	Economically developed and developing countries	Unknown	Young adults	Possibly males (limited data)h	0.5–1%c
5	No	Faecal-oral	Unknown	Unknown	Unknown	Unknown	Unknown
6	No	Faecal-oral	Unknown	Unknown	Unknown	Unknown	Unknown
7	Yes	Foodborne; Faecal-oral; blood transfusion?	Unknown	Unknown	Unknown	Unknown	Unknown
8	No	Faecal-oral	Unknown	Unknown	Unknown	Unknown	Unknown

^aPathak and Barde (2017)

^bSpina et al. (2017)

^cPeron et al. (2007)

^dKumar et al. (2017)

^eJin et al. (2016)

^fKamar et al. (2014)

^gHorvatits et al. (2019)

^hMizuo et al. (2005)