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. 2021 May 12;12(5):476. doi: 10.1038/s41419-021-03761-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Heatmap of β cell identity genes. B Venn diagrams of upregulated (red) and downregulated (blue) genes enriched in β and α cell by A-485 treatment. C Heatmap of α cell identity genes, islet hormone genes, and progenitor markers. D Heatmap of disallowed genes and related methylases and demethylases. E–F Isolated rat islets were treated with 3 μM A-485 for 16 h and mRNA levels of β and α cell identity genes were detected by RT-qPCR. Data are given as mean ± SD for three separate experiments. ***p < 0.001 vs control group.