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. 2021 May 12;12(5):476. doi: 10.1038/s41419-021-03761-1

Fig. 4. CBP/p300 HAT mediates expression of Hadh responsible for basal insulin secretion.

Fig. 4

A mRNA and protein levels of Hadh and Foxa2 in isolated rat islets treated with A-485 for 16 h. B Representative pancreatic sections co-immunostained for insulin (Ins, green), Hadh (red), and DAPI (blue) from control and A-485-treated C57BL/6 mice (scale bars, 20 μm). C Blood glucose levels of 4-week db/m and db/db mice were measured after 16 h fasting. D Fasting serum insulin levels of 4-week db/m and db/db mice. E Serum insulin levels after glucose loading in 4-week db/m and db/db mice (n = 5). F Isolated islets from 4-week-old db/m and db/db mice were stimulated with 5.6 mM glucose for 1 h to measure insulin secretion. G–J Representative pancreatic sections co-immunostained for insulin (Ins, green), Hadh/MafA/Glut2/CBP/p300 (red), and DAPI (blue) from 4-week-old db/m and db/db mice (scale bars, 20 μm). Data are given as mean ± SD. * p < 0.05, **p < 0.01, ***p < 0.001 vs control group, #p < 0.001 vs 0 min.