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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Pediatr Nephrol. 2020 Nov 13;36(9):2607–2614. doi: 10.1007/s00467-020-04812-z

Figure 2. The GTPase cycle of regulatory GTPases.

Figure 2.

When in the GTP-bound state, these enzymes interact with cell-type specific downstream effectors, thus activating actin nucleators and actin crosslinking proteins. GTP hydrolysis requires the binding of GTPase activating proteins (GAPs), and a subsequent switch into the GDP-bound conformation disengages interactions between GTPase and upstream effectors. Interactions with GDP exchange factors (GEF) promotes re-activation of the GTPase. Examples of the regulatory proteins are indicated in the figure. GTPase cycle of large GTPase Dynamin (Dyn) is regulated by its oligomerization status, with dimers and tetramers being inactive form of the enzyme and rings being the active form of the enzyme.