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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Pediatr Nephrol. 2020 Nov 13;36(9):2607–2614. doi: 10.1007/s00467-020-04812-z

Table 1.

Actin binding proteins in podocytes

Protein Function in podocytes Binding partners Reference
Actin monomer (G-actin binding)
Profilin Actin nucleotide exchange factor Inf2 [57]
Nucleators
Arp2/3-complex Branched actin networks WASP, WAVE [38]
Formins:
Inf2 (inverted formin 2) Unbranched actin structures mDia [41]
mDia Unbranched actin structures Inf2 [41]
Elongation-promoting factors
Ena/VASP Accelerate elongation and prevent capping WAVE, Profilin [58]
Barbed end capping
CapZ Caps barbed ends of filaments Inf2 [57]
Gelsolin Severs actin filaments, and caps barbed ends of filaments [35]
Crosslinking/Bundling
Non-muscle myosin II Actin crosslinking and contractile properties [59, 60]
Non-muscle myosin I (Myo1e) Actin crosslinking and contractile properties [45]
α-actinin 4 Crosslinks actin filaments [13]